New clinical trial for treatment of LF in Cote d’Ivoire

DOLF project studies have demonstrated the safety and superior efficacy of IDA (a triple drug regimen of ivermectin, DEC, and albendazole) for treatment of lymphatic filariasis (LF). Moxidectin is a new drug that was recently approved for treatment of onchocerciasis. It is more effective than ivermectin for long-term clearance of O. volvulus parasites from the […]

DOLF Project Ophthalmologists Publish Short Case Report

DOLF project ophthalmologists Michael Gyasi and Augustine Hong have published a short case report of a patient with ocular onchocerciasis. This includes a photo and a very interesting video with motile microfilariae in the anterior chamber of the eye (open access, see “supplements”) that people may want to use for teaching or social mobilization. Microfilarial […]

Update on IDA treatment published

DOLF researchers provide update on long term effect of IDA triple drug treatment for lymphatic filariasis. N Engl J Med. 2018;382(20):1956-1957

DOLF Laboratory Core Improves Microscopy Technology

The lab in St. Louis received an Olympus VS120-S6 microscope and slide scanner. Microscopy is essential to study the effect of drugs on adult Onchocerca volvulus worms. However, drug-related morphological changes are sometimes difficult to differentiate from age-related changes of the worms. Unfortunately, is the technical expertise to judge worms in histological nodule sections vanishing […]