DOLF Presentations – ASTMH Meeting

DOLF Presentations at the Annual Meeting of the American Society of Tropical Medicine and Hygiene (Virtual, November 2021) Symposium: Clinical development of new treatments to support the global elimination of onchocerciasis. GJ Weil, C Hanson, N Opoku, A Hoerauf, S. Specht, M Sullivan. Coverage and impact of a single dose of ivermectin, DEC and albendazole […]

DOLF team recognized for their research on LF in Ivory Coast

DOLF researchers Benjamin Koudou, Allassane Ouattara, Catherine Bjerum, and colleagues were recently honored to receive the 11th CSRS-Eremitage Fund Prize for Scientific Research in Partnership from the Swiss Center for Scientific Research in Côte d’Ivoire. The prize recognizes the team’s pioneering research on new treatments for lymphatic filariasis, a disabling and disfiguring parasitic disease that […]

Highlighting DOLF Publications

First Half of 2021 Eneanya OA, Koudou BG, Aboulaye M, Elvis AA, Souleymane Y, Kouakou MM, Weil GJ, Fischer PU. Progress towards onchocerciasis elimination in Côte d’Ivoire: A geospatial modelling study. PLoS Negl Trop Dis. 2021 Feb 10;15(2):e0009091. doi:10.1371/journal.pntd.0009091. eCollection 2021 Feb PMID: 33566805. This study reviewed dramatic improvements in onchocerciasis endemicity that have occurred […]

Publications from Clinical Trials

The DOLF project is pleased to share several recent publications from clinical trials and community studies of alternative treatments for lymphatic filariasis. All of these have been published with open access. The first two articles (by Campillo et al and Ouattara et al) provide further strong evidence in support of the WHO recommendation to use […]

The DOLF Program welcomes Nicole Fetcho as the new Program Manager

Previously Nicole was DOLF’s Data Manager for 15 months before stepping into the role as Program Manager. Nicole served for one year in AmeriCorps conducting HIV prevention with high-risk populations in Cleveland, Ohio. After AmeriCorps, Nicole received her Master’s in Public Health from the Brown School at Washington University in St. Louis with a specialization […]

New clinical trial for treatment of LF in Cote d’Ivoire

DOLF project studies have demonstrated the safety and superior efficacy of IDA (a triple drug regimen of ivermectin, DEC, and albendazole) for treatment of lymphatic filariasis (LF). Moxidectin is a new drug that was recently approved for treatment of onchocerciasis. It is more effective than ivermectin for long-term clearance of O. volvulus parasites from the […]

DOLF Project Ophthalmologists Publish Short Case Report

DOLF project ophthalmologists Michael Gyasi and Augustine Hong have published a short case report of a patient with ocular onchocerciasis. This includes a photo and a very interesting video with motile microfilariae in the anterior chamber of the eye (open access, see “supplements”) that people may want to use for teaching or social mobilization. Microfilarial […]

Update on IDA treatment published

DOLF researchers provide update on long term effect of IDA triple drug treatment for lymphatic filariasis. N Engl J Med. 2018;382(20):1956-1957

DOLF Laboratory Core Improves Microscopy Technology

The lab in St. Louis received an Olympus VS120-S6 microscope and slide scanner. Microscopy is essential to study the effect of drugs on adult Onchocerca volvulus worms. However, drug-related morphological changes are sometimes difficult to differentiate from age-related changes of the worms. Unfortunately, is the technical expertise to judge worms in histological nodule sections vanishing […]