Indonesia

Impact and cost effectiveness of annual vs. semiannual MDA for elimination of brugian LF in Indonesia

Optimization of Mass Drug Administration with Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis

Study Site: Sikka District

The objective of this study is to compare the treatment effect of MDA with Albendazole and Diethylcarbamazine delivered once per year to MDA delivered twice per year. Two filarial parasite species, Brugia timori and W. bancrofti, were found in the area. Our results from Sikka show that annual MDA was sufficient to reduce Mf prevalence to less than 1% in areas with low to moderate baseline prevalence, while semiannual MDA was useful for rapidly reducing Mf prevalence in an area with higher baseline endemicity (Supali et al. 2019).

Comparison of Binax Filariasis Now Test and Alere Filariasis Test Strip for the detection of circulating W. bancrofti antigens in low prevalence areas after MDA.

Study Site: Pekalongan District

The special epidemiological situation in Pekalongan (low residual LF infection rates following MDA) makes it ideal for comparing the Binax Now ICT card test and the Alere filariasis strip test. Results from this study agree with similar studies from other sites that find the Alere test strips are more sensitive than the Binax Now test (Yahathugoda et al. 2015).

Comparison of DEC/Albendazole (DA) and Ivermectin/DEC/Albendazole (IDA) for the elimination of LF caused by B. timori.

Study Sites: Sumba Barat Daya and Flores Timur Districts

This study shows that IDA is as safe as DA, but more effective to clear B. timori Mf one year after treatment compared to DA. IDA is also more effective compared to DO for the treatment of Trichuris trichiura infection. Results of these studies are currently being analyzed and prepared for publication.

Research Collaborator

Prof. Dr. Taniawati Supali
Department of Parasitology
Universitas Indonesia
Jakarta INDONESIA