India (Concluded)

Study Site: Yadgir district, Karnataka


Safety and efficacy of IDA as a mass drug administration regimen for elimination of lymphatic filariasis

Study Site: Yadgir district, Karnataka

This study compared the safety and efficacy of mass drug administration (MDA) with triple drug regimen of ivermectin, diethylcarbamazine, and albendazole “IDA” with the standard MDA treatment regimen of diethylcarbamazine (DEC) and albendazole “DA”. The results showed that IDA and DA had comparable safety profiles and that both regimens were acceptable to the population. Follow-up studies showed that IDA was superior to DA for clearing microfilaremia, an important indicator of infection.

Implementation Partners

Research Collaborator

Dr. P. Jambulingam, Director, ICMR-VCRC, Puducherry, India

Coordinating Investigators

Washington University School of Medicine, St. Louis, Missouri
Dr. Gary Weil and Dr. Ramakrishna Rao