Haiti

Safety and efficacy of IDA as a mass drug administration regimen for elimination of lymphatic filariasis

Study Site: Cap-Haitien

This study compared the safety and efficacy of mass drug administration (MDA) with triple drug regimen of ivermectin, diethylcarbamazine, and albendazole “IDA” with the standard MDA treatment regimen of diethylcarbamazine (DEC) and albendazole “DA”. The results showed that IDA and DA had comparable safety profiles and that both regimens were acceptable to the population. Follow-up studies showed that IDA was superior to DA for clearing microfilaremia, an important indicator of infection.

Investigator

Ministére de la Santé Publique et de la Population, Port au Prince, Haiti
Dr. Jean Frantz Lemoine

Coordinating Investigator

Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA
Dr. Christine Dubray