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Philip J. Budge, Carly Herbert, Britt J. Andersen, Gary J. Weil
Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature
www.plosntds.org
www.plosntds.org
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(22)Tj
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(24)Tj
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(31)Tj
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()Tj
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0 g
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(onchocerciasis)Tj
6.0661 0 Td
(or)Tj
1.0999 0 Td
(loiasis)Tj
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([)Tj
0.83 0.64 0.02 0 k
(37)Tj
0 g
(].)Tj
2.0807 0 Td
(DEC)Tj
2.1883 0 Td
(is)Tj
0.8447 0 Td
(therefore)Tj
3.8551 0 Td
(not)Tj
1.5761 0 Td
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1.0375 0 Td
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2.245 0 Td
(of)Tj
1.0148 0 Td
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-33.2388 -1.2982 Td
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2.6475 0 Td
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1.2869 0 Td
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(co-endemic)Tj
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/F11 1 Tf
1.9955 0 Td
[()]TJ
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(.)Tj
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1.1396 0 Td
[()3()10()15()-13()4()12()-4()]TJ
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3.4128 0 Td
(or)Tj
/F11 1 Tf
1.0999 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
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0.9694 0 Td
[()4()4()]TJ
/F7 1 Tf
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1.6328 0 Td
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2.7439 0 Td
(pharmacologic)Tj
6.1625 0 Td
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-35.053 -1.2983 Td
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-33.5619 -1.2982 Td
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([)Tj
0.83 0.64 0.02 0 k
(19)Tj
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(,)Tj
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1.7348 0 Td
(38)Tj
0 g
(].)Tj
-33.1594 -1.304 Td
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4.5921 0 Td
(\(IVM\).)Tj
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(IVM)Tj
2.143 0 Td
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5.6976 0 Td
(member)Tj
3.583 0 Td
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1.0148 0 Td
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1.4683 0 Td
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2.0466 0 Td
(of)Tj
1.0148 0 Td
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-31.9972 -1.2982 Td
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3.7303 0 Td
(initially)Tj
3.2485 0 Td
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2.2053 0 Td
(fermentation)Tj
5.4482 0 Td
(products)Tj
3.753 0 Td
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1.0148 0 Td
[()10(\r)7()20()2()12(\r)11()11()24()3()7()8()]TJ
5.2724 0 Td
[()22()3()2()-9()18()14(\r)7()4()12()-4()]TJ
/F7 1 Tf
(.)Tj
4.5581 0 Td
(IVM)Tj
2.1486 0 Td
(treat-)Tj
-34.6674 -1.304 Td
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2.3073 0 Td
(for)Tj
1.389 0 Td
(LF)Tj
1.2869 0 Td
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1.6951 0 Td
(first)Tj
1.8085 0 Td
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3.6567 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(late)Tj
1.6214 0 Td
(1980s)Tj
2.4831 0 Td
([)Tj
0.83 0.64 0.02 0 k
(39)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(41)Tj
0 g
(])Tj
3.3222 0 Td
(and)Tj
1.7292 0 Td
(15)Tj
1.1735 0 Td
(early)Tj
2.1486 0 Td
(safety)Tj
2.4775 0 Td
(and)Tj
1.7348 0 Td
(efficacy)Tj
3.2201 0 Td
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-34.5597 -1.2982 Td
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1.0147 0 Td
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2.1487 0 Td
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1.3833 0 Td
(bancroftian)Tj
4.8472 0 Td
(filariasis)Tj
3.5149 0 Td
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2.126 0 Td
(reviewed)Tj
3.7927 0 Td
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1.0375 0 Td
(a)Tj
0.652 0 Td
(1997)Tj
2.126 0 Td
(meta)Tj
2.194 0 Td
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3.3278 0 Td
([)Tj
0.83 0.64 0.02 0 k
(42)Tj
0 g
(].)Tj
2.075 0 Td
(IVM)Tj
2.1486 0 Td
(dosing)Tj
2.897 0 Td
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-35.2854 -1.2983 Td
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1.2869 0 Td
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2.5285 0 Td
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(roughly)Tj
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(to)Tj
1.0261 0 Td
(150200)Tj
/F14 1 Tf
3.5886 0 Td
[()]TJ
/F7 1 Tf
(g/kg.)Tj
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2.6476 0 Td
(dose)Tj
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-33.3408 -1.3039 Td
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3.2881 0 Td
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0.6463 0 Td
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2.3357 0 Td
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4.4901 0 Td
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1.389 0 Td
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2.8062 0 Td
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1.4627 0 Td
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1.7972 0 Td
(five)Tj
1.6497 0 Td
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-31.6571 -1.2983 Td
(following)Tj
3.9798 0 Td
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2.1429 0 Td
(begins)Tj
2.795 0 Td
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1.0148 0 Td
(early)Tj
2.1486 0 Td
(as)Tj
1.0148 0 Td
(30)Tj
1.1736 0 Td
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1.9955 0 Td
(post-treatment)Tj
6.1682 0 Td
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2.0012 0 Td
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4.2917 0 Td
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3.8324 0 Td
(out)Tj
1.5534 0 Td
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1.0261 0 Td
(6)Tj
-35.138 -1.2982 Td
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3.2824 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(25)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3947 0 Td
(40)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.4003 0 Td
(41)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3946 0 Td
(43)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(46)Tj
0 g
(].)Tj
3.2032 0 Td
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1.9899 0 Td
(rapid)Tj
2.3357 0 Td
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1.4003 0 Td
(clearance)Tj
3.9515 0 Td
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2.8346 0 Td
(with)Tj
1.9956 0 Td
(doses)Tj
2.3981 0 Td
(as)Tj
1.0148 0 Td
(low)Tj
1.6611 0 Td
(as)Tj
1.0148 0 Td
(20)Tj
/F14 1 Tf
1.1678 0 Td
[()]TJ
/F7 1 Tf
(g/kg)Tj
-34.1742 -1.304 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7347 0 Td
(39)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.3947 0 Td
(46)Tj
0 g
(],)Tj
1.7404 0 Td
(but)Tj
1.5534 0 Td
(higher)Tj
2.8006 0 Td
(doses)Tj
2.3981 0 Td
(\(200)Tj
1.9899 0 Td
(to)Tj
1.0262 0 Td
(400)Tj
/F14 1 Tf
1.6441 0 Td
[()]TJ
/F7 1 Tf
(g/kg\))Tj
2.8232 0 Td
(may)Tj
1.9276 0 Td
(have)Tj
2.0636 0 Td
(a)Tj
0.652 0 Td
(more)Tj
2.3414 0 Td
(prolonged)Tj
4.3369 0 Td
(effect)Tj
2.3641 0 Td
([)Tj
0.83 0.64 0.02 0 k
(47)Tj
0 g
(].)Tj
2.075 0 Td
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-34.8659 -1.2982 Td
(DEC,)Tj
2.4151 0 Td
(single)Tj
2.5284 0 Td
(dose)Tj
2.041 0 Td
(IVM)Tj
2.1486 0 Td
(has)Tj
1.5421 0 Td
(little)Tj
1.9955 0 Td
(or)Tj
1.0999 0 Td
(no)Tj
1.2756 0 Td
(effect)Tj
2.364 0 Td
(on)Tj
1.2756 0 Td
(filarial)Tj
2.778 0 Td
(antigen)Tj
3.2031 0 Td
(levels)Tj
2.3754 0 Td
([)Tj
0.83 0.64 0.02 0 k
(48)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(50)Tj
0 g
(],)Tj
3.5433 0 Td
(suggesting)Tj
4.405 0 Td
(a)Tj
0.652 0 Td
(lack)Tj
-35.6426 -1.2983 Td
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1.0147 0 Td
(macrofilaricidal)Tj
6.548 0 Td
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2.5909 0 Td
(IVM)Tj
2.143 0 Td
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0.8504 0 Td
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4.6771 0 Td
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0.9524 0 Td
(repeated)Tj
3.6397 0 Td
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2.0126 0 Td
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1.0374 0 Td
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4.3484 0 Td
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3.3278 0 Td
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-35.5405 -1.2982 Td
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0.8447 0 Td
(not)Tj
1.576 0 Td
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2.3811 0 Td
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1.0205 0 Td
(children)Tj
3.5603 0 Td
(weighing)Tj
3.8664 0 Td
(less)Tj
1.6101 0 Td
(than)Tj
2.0296 0 Td
(15)Tj
1.1735 0 Td
(kg)Tj
1.1792 0 Td
(or)Tj
1.0998 0 Td
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1.0262 0 Td
(pregnant)Tj
3.8267 0 Td
(women)Tj
3.2032 0 Td
(during)Tj
2.9253 0 Td
(MDA)Tj
2.5341 0 Td
(for)Tj
1.3833 0 Td
(LF)Tj
1.287 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
-36.527 -1.304 Td
(51)Tj
0 g
(].)Tj
1.7347 0 Td
(As)Tj
1.2643 0 Td
(with)Tj
2.0012 0 Td
(DEC,)Tj
2.4095 0 Td
(IVM)Tj
2.1486 0 Td
(can)Tj
1.6271 0 Td
(precipitate)Tj
4.4617 0 Td
(severe)Tj
2.6759 0 Td
(encephalopathy)Tj
6.5026 0 Td
(and)Tj
1.7348 0 Td
(death)Tj
2.4265 0 Td
(when)Tj
2.4037 0 Td
(given)Tj
2.3811 0 Td
(to)Tj
1.0261 0 Td
(per-)Tj
-34.7978 -1.2982 Td
(sons)Tj
1.9955 0 Td
(heavily)Tj
3.0274 0 Td
(infected)Tj
3.4186 0 Td
(with)Tj
/F11 1 Tf
2.0012 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F11 1 Tf
0.9695 0 Td
[()4()4()]TJ
/F7 1 Tf
1.4116 0 Td
([)Tj
0.83 0.64 0.02 0 k
(52)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(53)Tj
0 g
(],)Tj
1.7348 0 Td
(and)Tj
1.7348 0 Td
(is)Tj
0.8447 0 Td
(not)Tj
1.5761 0 Td
(used)Tj
2.0579 0 Td
(as)Tj
1.0148 0 Td
(MDA)Tj
2.5341 0 Td
(for)Tj
1.3833 0 Td
(LF)Tj
1.287 0 Td
(in)Tj
1.0374 0 Td
(areas)Tj
2.2451 0 Td
(with)Tj
1.9955 0 Td
(high)Tj
-34.0041 -1.2983 Td
(intensity)Tj
/F11 1 Tf
3.685 0 Td
[()]TJ
/F7 1 Tf
(.)Tj
/F11 1 Tf
0.9751 0 Td
[()4()4()]TJ
/F7 1 Tf
1.406 0 Td
(infections.)Tj
-4.8699 -1.3039 Td
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5.1817 0 Td
(\(ALB\).)Tj
2.931 0 Td
(ALB)Tj
2.0182 0 Td
(belongs)Tj
3.2825 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(benzimidazole)Tj
6.0151 0 Td
(group)Tj
2.6078 0 Td
(of)Tj
1.0148 0 Td
(anthelminthic)Tj
5.8507 0 Td
(agents)Tj
2.7496 0 Td
(and)Tj
-0.02 Tc
-35.3421 -1.2983 Td
(is)Tj
0.8163 0 Td
(thought)Tj
3.2598 0 Td
(to)Tj
0.9922 0 Td
(inhibit)Tj
2.7892 0 Td
(tubulin)Tj
3.0331 0 Td
(polymerization)Tj
6.0718 0 Td
(leading)Tj
3.016 0 Td
(to)Tj
0.9978 0 Td
(immobilization)Tj
6.1625 0 Td
(and)Tj
1.6837 0 Td
(death)Tj
2.3528 0 Td
(of)Tj
0.9808 0 Td
(susceptible)Tj
-32.156 -1.3039 Td
(helminths.)Tj
4.3029 0 Td
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1.9729 0 Td
(meta-analyses)Tj
5.6012 0 Td
(of)Tj
0.9865 0 Td
(ALB)Tj
1.9729 0 Td
(combination)Tj
5.1704 0 Td
(therapy)Tj
3.1351 0 Td
(for)Tj
1.3379 0 Td
(LF)Tj
1.2529 0 Td
(published)Tj
3.9855 0 Td
(in)Tj
1.0034 0 Td
(2005)Tj
2.058 0 Td
(disagreed)Tj
-32.7796 -1.2983 Td
(regarding)Tj
3.9514 0 Td
(ALB's)Tj
2.5172 0 Td
(value)Tj
2.2223 0 Td
(for)Tj
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(40)Tj
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(44)Tj
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(45)Tj
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(54)Tj
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(56)Tj
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(69)Tj
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(73)Tj
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(68)Tj
0 g
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-34.6448 -1.3039 Td
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(lymphedema)Tj
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(76)Tj
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(15)Tj
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(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(17)Tj
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(,)Tj
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1.389 0 Td
(44)Tj
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(,)Tj
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1.3889 0 Td
(45)Tj
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(,)Tj
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1.389 0 Td
(55)Tj
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0.83 0.64 0.02 0 k
1.389 0 Td
(59)Tj
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(66)Tj
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(72)Tj
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0.83 0.64 0.02 0 k
1.3889 0 Td
(77)Tj
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(].)Tj
1.7292 0 Td
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-32.8533 -1.3039 Td
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1.9786 0 Td
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(17)Tj
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(44)Tj
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(63)Tj
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1.3946 0 Td
(78)Tj
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(];)Tj
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1.0205 0 Td
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1.474 0 Td
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3.5829 0 Td
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6.548 0 Td
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(15)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
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(59)Tj
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1.3946 0 Td
(77)Tj
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(].)Tj
1.7348 0 Td
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(79)Tj
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0.83 0.64 0.02 0 k
(81)Tj
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(].)Tj
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-27.6433 -1.2983 Td
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4.7338 0 Td
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3.8778 0 Td
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3.0671 0 Td
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3.8664 0 Td
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3.3959 0 Td
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(16)Tj
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(22)Tj
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(30)Tj
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(34)Tj
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(38)Tj
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(39)Tj
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1.3946 0 Td
(43)Tj
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(47)Tj
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(54)Tj
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(65)Tj
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3.2031 0 Td
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3.3959 0 Td
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(47)Tj
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0.83 0.64 0.02 0 k
1.7348 0 Td
(67)Tj
0 g
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0.83 0.64 0.02 0 k
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(74)Tj
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1.3889 0 Td
(77)Tj
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(85)Tj
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(89)Tj
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(67)Tj
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