The DOLF Project
DOLF project studies have demonstrated the safety and superior efficacy of IDA (a triple drug regimen of ivermectin, DEC, and albendazole) for treatment of lymphatic filariasis (LF). Moxidectin is a new drug that was recently approved for treatment of onchocerciasis. It is more effective than ivermectin for long-term clearance of O. volvulus parasites from the […]
DOLF project ophthalmologists Michael Gyasi and Augustine Hong have published a short case report of a patient with ocular onchocerciasis. This includes a photo and a very interesting video with motile microfilariae in the anterior chamber of the eye (open access, see “supplements”) that people may want to use for teaching or social mobilization. Microfilarial […]
DOLF researchers provide update on long term effect of IDA triple drug treatment for lymphatic filariasis. N Engl J Med. 2018;382(20):1956-1957
The DOLF team recently collaborated with the Universitas Indonesia, Jakarta and the Indonesian Ministry of Health to host a 1.5-day meeting in early February in Jakarta to discuss strategic planning for the upcoming rollout of IDA mass drug administration (MDA) in the country. The attendee list also included a representative of the Bill and Melinda […]
The lab in St. Louis received an Olympus VS120-S6 microscope and slide scanner. Microscopy is essential to study the effect of drugs on adult Onchocerca volvulus worms. However, drug-related morphological changes are sometimes difficult to differentiate from age-related changes of the worms. Unfortunately, is the technical expertise to judge worms in histological nodule sections vanishing […]
Dr. Christopher King and his team from Case Western Reserve University and Dr. Alison Krentel from the Bruyere Research Institute in Ottawa have returned to East New Britain to continue their research. Dr. Krentel will train local staff on procedures for assessing the acceptability of the triple drug mass drug administration that was provided province-wide […]
Researchers uncover molecular changes associated with treating lymphatic filariasis
New Global Health Program Manager (Operations) – The DOLF Project Teresa joins the DOLF project as the Global Health Program Manager for Operations taking over for Rachel Anderson. She joins us with two years of health care research and data analysis experience at the State of Massachusetts’s Center for Health Information and Analysis. Prior to […]
The DOLF Project is proud to announce publication in PLOS Medicine of results form a major safety study investigating the use of a triple drug combination “IDA” as a treatment regimen for lymphatic filariasis. The study enrolled more than 26,000 participants in five countries. Results from this study suggest that IDA is safe enough for […]
TRANSLATIONAL AND OPERATIONAL FIELD RESEARCH ON LYMPHATIC FILARIASIS AND ONCHOCERCIASIS Our group at Washington University School of Medicine in St. Louis has funding from the Bill & Melinda Gates Foundation to conduct cutting-edge research to support elimination programs for lymphatic filariasis and onchocerciasis. We are seeking postdoctoral fellows to (1) participate in applied field research […]
DOLF Researcher Dr. Christine Dubray, a medical epidemiologist at the Centers for Disease Control and Prevention in Atlanta, was the keynote speaker for the Washington University Medical School’s 21st Global Health & Medicine Symposium held on April 17. The title of her talk was, “A global health career on the front lines, and what I […]
Bill & Melinda Gates Foundation supports DOLF research to fight elephantiasis, river blindness
DOLF investigators Christopher King and James Kazura from Case Western Reserve University in Cleveland with colleagues at the Papua New Guinea Institute for Medical Research and at Washington University in St. Louis have just published important results from a randomized clinical trial. This trial tested the safety and efficacy of a new triple drug treatment […]
Identifying solutions for enrollment, regulatory requirements, drug procurement, and improved collaboration for an international clinical trial in Hohoe Ghana By Rachel Bick and Philip Budge October 5, 2018 The DOLF Project recently sent two team members, Philip Budge and Rachel Bick, to visit the Nick Opoku and the DOLF Onchocerciasis research team in Hohoe, Ghana. […]
2018 Summer Research Program Reflections – Complexities Behind Lymphatic Filariasis July 12,2018 The blog is following the student participants in this year’s Institute for Public Health Summer Research Program (https://publichealth. wustl.edu/resources/summer-research program/). Each student will be providing their own reflections from a Summer Research Program Seminar Series (https://publichealth. wustl.edu/series/summer-research program-seminars/ ) event. Some students will […]
At the 2018 GAELF Meeting, Dr. Gary Weil shared perspectives on how the new treatment combination (IDA) could accelerate elimination of LF.
January 28, 2010 By Michael C. Purdy Washington University School of Medicine in St. Louis has received a five-year, $13 million grant from the Bill & Melinda Gates Foundation to improve efforts to eliminate two parasitic diseases, elephantiasis and river blindness. These diseases belong to a group of infections known as neglected tropical diseases, which […]