Eleven DOLF Project publications on triple drug (IDA) mass drug administration for elimination of lymphatic filariasis have now been bundled as a PLoS Collection

PloS “Collections” are useful for readers and researchers alike, because provide easy access to related articles on high priority topics that have been published in PLoS journals at different times. This collection (published June 16, 2022) focuses on clinical trials and community studies of the safety, efficacy, and acceptability of the triple drug regimen IDA […]

The DOLF Team’s Work to Improve Prospects for Elimination of LF Featured in a Special Supplement Published in the Am. J. Trop. Med. Hyg. (March 2022)

The DOLF project (www.dolfproject.wustl.edu) led clinical trials and community studies of the safety and efficacy of a single-dose triple-drug therapy (IDA) for Lymphatic Filariasis (LF). IDA is now being used in mass drug administration (MDA) programs in many countries to accelerate LF elimination. This work was supported by grants from the Bill & Melinda Gates […]

Development of new treatments for Riverblindness

Development of new treatments for Riverblindness: Facilitated histological assessment of Onchocerca volvulus nodules to detect treatment effects on adult worms Adult O. volvulus worms reside in subcutaneous nodules and can live up to 15 years. It requires special expert knowledge to differentiate natural morphological changes during its life span from changes induced by anti-filarial drugs […]

DOLF team to provide clinical care to men with hydrocele in Cote d’Ivoire

With support from the Bill and Melinda Gates Foundation, and in partnership with the local partner Swiss Center for Scientific research in Cote d’Ivoire and the Ivorian National NTD Program, DOLF investigators helped organizing surgical hydrocelectomy training this week in Agboville, Cote d’Ivoire.  Eight surgeons from various parts of Cote d’Ivoire, 2 nurses, and 2 […]

Welcome Betsy Abente, the DOLF Program’s new Global Health Program Manager for Administration and Finance

Joining the team in November, Betsy brings over 15 years of global health experience, including nearly a decade of research administration at Washington University to the team. In her previous role as Associate Director for the International Center for Child Health and Development, she helped develop and manage the center’s growing capacity building arm as […]

DOLF Presentations – ASTMH Meeting

DOLF Presentations at the Annual Meeting of the American Society of Tropical Medicine and Hygiene (Virtual, November 2021) Symposium: Clinical development of new treatments to support the global elimination of onchocerciasis. GJ Weil, C Hanson, N Opoku, A Hoerauf, S. Specht, M Sullivan. Coverage and impact of a single dose of ivermectin, DEC and albendazole […]

DOLF team recognized for their research on LF in Ivory Coast

DOLF researchers Benjamin Koudou, Allassane Ouattara, Catherine Bjerum, and colleagues were recently honored to receive the 11th CSRS-Eremitage Fund Prize for Scientific Research in Partnership from the Swiss Center for Scientific Research in Côte d’Ivoire. The prize recognizes the team’s pioneering research on new treatments for lymphatic filariasis, a disabling and disfiguring parasitic disease that […]

Highlighting DOLF Publications

First Half of 2021 Eneanya OA, Koudou BG, Aboulaye M, Elvis AA, Souleymane Y, Kouakou MM, Weil GJ, Fischer PU. Progress towards onchocerciasis elimination in Côte d’Ivoire: A geospatial modelling study. PLoS Negl Trop Dis. 2021 Feb 10;15(2):e0009091. doi:10.1371/journal.pntd.0009091. eCollection 2021 Feb PMID: 33566805. This study reviewed dramatic improvements in onchocerciasis endemicity that have occurred […]

Publications from Clinical Trials

The DOLF project is pleased to share several recent publications from clinical trials and community studies of alternative treatments for lymphatic filariasis. All of these have been published with open access. The first two articles (by Campillo et al and Ouattara et al) provide further strong evidence in support of the WHO recommendation to use […]

Dr. Fatorma Bolay

Dr. Fatorma Bolay, the director of the Division of Public Health Research at the National Public Health Institute of Liberia (NPHIL) has passed away. He was the director of the former Liberian Institute for Biomedical Research (LIBR) and DOLF-Project collaborator since 2011. Dr. Bolay navigated the LIBR through difficult times in Liberia and was a […]

Onchocerciasis elimination in Côte d’Ivoire

The DOLF Project has just published an article on the spatial distribution of onchocerciasis (Oncho) in Côte d’Ivoire before and after the introduction of mass distribution of ivermectin. This work was based on extensive Ministry of Health mapping and surveillance data collected between 1975 and 2016. Data included village geolocations, village-level prevalence and intensity estimates […]

Publication on IDA in India

The DOLF Project (dolfproject.wustl.edu) is proud to announce publication of an important paper on the safety and efficacy of a triple drug combination treatment (IDA) for lymphatic filariasis (LF) in India. With almost 9,000 participants, this was the largest of five IDA safety and efficacy studies that DOLF coordinated with financial support from the Bill […]

The DOLF Program welcomes Nicole Fetcho as the new Program Manager

Previously Nicole was DOLF’s Data Manager for 15 months before stepping into the role as Program Manager. Nicole served for one year in AmeriCorps conducting HIV prevention with high-risk populations in Cleveland, Ohio. After AmeriCorps, Nicole received her Master’s in Public Health from the Brown School at Washington University in St. Louis with a specialization […]

New clinical trial for treatment of LF in Cote d’Ivoire

DOLF project studies have demonstrated the safety and superior efficacy of IDA (a triple drug regimen of ivermectin, DEC, and albendazole) for treatment of lymphatic filariasis (LF). Moxidectin is a new drug that was recently approved for treatment of onchocerciasis. It is more effective than ivermectin for long-term clearance of O. volvulus parasites from the […]

DOLF Project Ophthalmologists Publish Short Case Report

DOLF project ophthalmologists Michael Gyasi and Augustine Hong have published a short case report of a patient with ocular onchocerciasis. This includes a photo and a very interesting video with motile microfilariae in the anterior chamber of the eye (open access, see “supplements”) that people may want to use for teaching or social mobilization. Microfilarial […]

Update on IDA treatment published

DOLF researchers provide update on long term effect of IDA triple drug treatment for lymphatic filariasis. N Engl J Med. 2018;382(20):1956-1957

DOLF Team Collaborates for Upcoming IDA Rollout in Indonesia

The DOLF team recently collaborated with the Universitas Indonesia, Jakarta and the Indonesian Ministry of Health to host a 1.5-day meeting in early February in Jakarta to discuss strategic planning for the upcoming rollout of IDA mass drug administration (MDA) in the country. The attendee list also included a representative of the Bill and Melinda […]

DOLF Laboratory Core Improves Microscopy Technology

The lab in St. Louis received an Olympus VS120-S6 microscope and slide scanner. Microscopy is essential to study the effect of drugs on adult Onchocerca volvulus worms. However, drug-related morphological changes are sometimes difficult to differentiate from age-related changes of the worms. Unfortunately, is the technical expertise to judge worms in histological nodule sections vanishing […]

DOLF Research-Roll-Out of IDA for LF Elimination in PNG (ENB)

Dr. Christopher King and his team from Case Western Reserve University and Dr. Alison Krentel from the Bruyere Research Institute in Ottawa have returned to East New Britain to continue their research. Dr. Krentel will train local staff on procedures for assessing the acceptability of the triple drug mass drug administration that was provided province-wide […]

DOLF initiates a trial of IDA triple drug treatment for Oncho

DOLF researchers and staff traveled to Hohoe, Ghana in December 2019 to work with Nick Opoku’s team at the University of Health and Allied Sciences to initiate a trial of the triple drug treatment IDA in persons with onchocerciasis. This study is testing the same IDA combination (ivermectin plus DEC and albendazole) that is so […]

Two New Members Join the DOLF Team

Nicole Fetcho joined the DOLF Project in October 2019 as a Statistical Data Analyst and Data Manager. Nicole is well prepared for this work with a Master of Public Health degree (with a focus on Biostati­­stics and Epidemiology) from the Brown School of Social Work at Washington University in St. Louis. Her MPH practicum work […]

Introducing Teresa Tufte – Global Health Program Manager

New Global Health Program Manager (Operations) – The DOLF Project Teresa joins the DOLF project as the Global Health Program Manager for Operations taking over for Rachel Anderson. She joins us with two years of health care research and data analysis experience at the State of Massachusetts’s Center for Health Information and Analysis. Prior to […]

DOLF Obtains $2.4 Million to Fund Research in Papua New Guinea

The DOLF project has received a 2.4 million dollar grant to support studies to assess the impact of an IDA implementation program in East New Britain province, Papua New Guinea (PNG) from the Bill & Melinda Gates Foundation . Prior DOLF studies have demonstrated the safety and efficacy of the “IDA” three-drug combination drug therapy […]

Major Publication Accepted to PLOS Medicine

The DOLF Project is proud to announce publication in PLOS Medicine of results form a major safety study investigating the use of a triple drug combination “IDA” as a treatment regimen for lymphatic filariasis. The study enrolled more than 26,000 participants in five countries. Results from this study suggest that IDA is safe enough for […]

POSTDOCTORAL FELLOWSHIPS

TRANSLATIONAL AND OPERATIONAL FIELD RESEARCH ON LYMPHATIC FILARIASIS AND ONCHOCERCIASIS Our group at Washington University School of Medicine in St. Louis has funding from the Bill & Melinda Gates Foundation to conduct cutting-edge research to support elimination programs for lymphatic filariasis and onchocerciasis. We are seeking postdoctoral fellows to (1) participate in applied field research […]

DOLF Researcher Dr. Christine Dubray Keynote Speaker

DOLF Researcher Dr. Christine Dubray, a medical epidemiologist at the Centers for Disease Control and Prevention in Atlanta, was the keynote speaker for the Washington University Medical School’s 21st Global Health & Medicine Symposium held on April 17. The title of her talk was, “A global health career on the front lines, and what I […]

DOLF Project Research On A New Treatment For LF Is Published In The NEJM

DOLF investigators Christopher King and James Kazura from Case Western Reserve University in Cleveland with colleagues at the Papua New Guinea Institute for Medical Research and at Washington University in St. Louis have just published important results from a randomized clinical trial. This trial tested the safety and efficacy of a new triple drug treatment […]

Behind the Scenes for the DOLF ONCHO Studies in Ghana:

Identifying solutions for enrollment, regulatory requirements, drug procurement, and improved collaboration for an international clinical trial in Hohoe Ghana By Rachel Bick and Philip BudgeOctober 5, 2018 The DOLF Project recently sent two team members, Philip Budge and Rachel Bick, to visit the Nick Opoku and the DOLF Onchocerciasis research team in Hohoe, Ghana. Our […]

Potentially Game-Changing Research for Treating Onchocerciasis has Started in Ghana

The DOLF project, a collaboration of partners from Africa, Asia, the U.S. and Europe, has secured a new grant of 2.1 Million dollars from the Bill and Melinda Gates Foundation. This grant will fund a clinical trial of a new treatment for onchocerciasis, a disease caused by parasitic worms that is also known as River […]

2018 Summer Research Program Reflections – Complexities Behind LF

2018 Summer Research Program Reflections  – Complexities Behind Lymphatic Filariasis July 12,2018 The blog is following the student participants in this year’s Institute for Public Health Summer Research  Program  (https://publichealth. wustl.edu/resources/summer-research­ program/). Each student will be providing their own reflections from a Summer Research Program Seminar Series (https://publichealth. wustl.edu/series/summer-research­ program-seminars/ ) event. Some students will […]

2018 GAELF Meeting – Media Report

At the 2018 GAELF Meeting, Dr. Gary Weil shared perspectives on how the new treatment combination (IDA) could accelerate elimination of LF.

Introduction – Global Health Research Program Manager

The DOLF project is pleased to announce that Rachel Bick has joined our team as Global Health Research Project Manager Rachel brings international experience in global health and a strong academic background to this role. She holds a Bachelor of Science in Human Factors Psychology degree from the University of Utah and a Master of Public Health […]

Uniting to Combat Neglected Tropical Diseases (NTDs)

Uniting to Combat Neglected Tropical Diseases (NTDs) released their fifth progress report on the London Declaration on NTDs. The report describes the progress made toward achieving the goals set out by the London Declaration toward the control, elimination, and eradication of 10 NTDs. DOLF research on a more effective triple drug combination for lymphatic filariasis […]

1st DOLF Meeting: October 11-14th, St. Louis, MO-USA

Top row: Eric Ottesen, Phillip Miller, Peter Fischer, Alex Debrah, Ron Don, Achim Hoerauf, Tom Kanyok, Julie Jacobson, Chris King, Kerstin Fischer, Tania Supali, Sabine Mand, Charles Mackenzie, Dan Goldberg, Kapa Ramaiah, Rao Ramakrishna, Andrew Majewski, Dao-Jun Jiang. Bottom row: Gary Weil, Amy Rush, Yao Sodahlon, Eddie Thomsen, Manasseh Baea, Fatorma Bolay, Amy Klion, Wilma […]

WUSTL receives $13 million Gates Foundation global health grant toward elimination of tropical diseases

January 28, 2010 By Michael C. Purdy Washington University School of Medicine in St. Louis has received a five-year, $13 million grant from the Bill & Melinda Gates Foundation to improve efforts to eliminate two parasitic diseases, elephantiasis and river blindness. These diseases belong to a group of infections known as neglected tropical diseases, which […]