The Role of Monkeys as a Reservoir for the Lymphatic Filarial Parasite Brugia malayi on Belitung Island, Indonesia

In May 2023 Irina Diekmann, a veterinarian and postdoc at Washington University, traveled to Belitung Island, Indonesia to assist Professor Taniawati Supali and her team at the Universitas Indonesia, trap crab-eating macaques for blood collection to determine if they are a potential animal reservoir of B. malayi. B. malayi, a filarial nematode and one of […]

DOLF Team Supports New Clinical Trial in Cote d’Ivoire

The DOLF Team Supports a New Clinical Trial in Côte d’Ivoire to Test Safety of Moxidectin in Regions co-Endemic to Onchocerciasis and Lymphatic Filiariasis Onchocerciasis (oncho), also known as river blindness, is a serious, debilitating, and stigmatizing parasitic disease. It is a major neglected tropical disease that causes severe skin disease and blindness in more […]

A New DOLF Publication Highlights Promising New Results in Support of Onchocerciasis Elimination

Onchocerciasis (“river blindness”), a parasitic disease that leads to debilitating and stigmatizing ailments, has been targeted by the World Health Organization for elimination. New drug treatments that kill or permanently sterilize female worms could accelerate this process. The DOLF team, together with our partners at the University of Health and Allied Sciences (UHAS) in Ghana […]

The DOLF Team’s 2022: Year in Review

As we look towards a new year, we wanted to share some highlights from 2022, a year that saw many new advances and developments in our research on Lymphatic Filariasis (LF) and Onchocerciasis (Oncho). LF research Cote d’Ivoire. In late winter, DOLF team members traveled to Côte d’Ivoire for 12-month follow-up visits for patients enrolled […]

Welcome to DOLF’s new Postdoctoral Research Associate- Dr. Adebiyi Adeniran

Adebiyi is a molecular entomologist and molecular parasitologist with over a decade of Neglected Tropical Disease (NTD) research and control program experience in sub-Saharan Africa and in Mexico. Adebiyi has  previously worked as the Regional Technical Lead for NTD diagnostics for Sightsavers UK, where he provided technical and advisory support to NTD control programs in […]

Eleven DOLF Project publications on triple drug (IDA) mass drug administration for elimination of lymphatic filariasis have now been bundled as a PLoS Collection

PloS “Collections” are useful for readers and researchers alike, because provide easy access to related articles on high priority topics that have been published in PLoS journals at different times. This collection (published June 16, 2022) focuses on clinical trials and community studies of the safety, efficacy, and acceptability of the triple drug regimen IDA […]

The DOLF Team’s Work to Improve Prospects for Elimination of LF Featured in a Special Supplement Published in the Am. J. Trop. Med. Hyg. (March 2022)

The DOLF project ( led clinical trials and community studies of the safety and efficacy of a single-dose triple-drug therapy (IDA) for Lymphatic Filariasis (LF). IDA is now being used in mass drug administration (MDA) programs in many countries to accelerate LF elimination. This work was supported by grants from the Bill & Melinda Gates […]

Welcome Betsy Abente, the DOLF Program’s new Global Health Program Manager for Administration and Finance

Joining the team in November, Betsy brings over 15 years of global health experience, including nearly a decade of research administration at Washington University to the team. In her previous role as Associate Director for the International Center for Child Health and Development, she helped develop and manage the center’s growing capacity building arm as […]

DOLF Presentations – ASTMH Meeting

DOLF Presentations at the Annual Meeting of the American Society of Tropical Medicine and Hygiene (Virtual, November 2021) Symposium: Clinical development of new treatments to support the global elimination of onchocerciasis. GJ Weil, C Hanson, N Opoku, A Hoerauf, S. Specht, M Sullivan. Coverage and impact of a single dose of ivermectin, DEC and albendazole […]

DOLF team recognized for their research on LF in Ivory Coast

DOLF researchers Benjamin Koudou, Allassane Ouattara, Catherine Bjerum, and colleagues were recently honored to receive the 11th CSRS-Eremitage Fund Prize for Scientific Research in Partnership from the Swiss Center for Scientific Research in Côte d’Ivoire. The prize recognizes the team’s pioneering research on new treatments for lymphatic filariasis, a disabling and disfiguring parasitic disease that […]

Highlighting DOLF Publications

First Half of 2021 Eneanya OA, Koudou BG, Aboulaye M, Elvis AA, Souleymane Y, Kouakou MM, Weil GJ, Fischer PU. Progress towards onchocerciasis elimination in Côte d’Ivoire: A geospatial modelling study. PLoS Negl Trop Dis. 2021 Feb 10;15(2):e0009091. doi:10.1371/journal.pntd.0009091. eCollection 2021 Feb PMID: 33566805. This study reviewed dramatic improvements in onchocerciasis endemicity that have occurred […]

Publications from Clinical Trials

The DOLF project is pleased to share several recent publications from clinical trials and community studies of alternative treatments for lymphatic filariasis. All of these have been published with open access. The first two articles (by Campillo et al and Ouattara et al) provide further strong evidence in support of the WHO recommendation to use […]

The DOLF Program welcomes Nicole Fetcho as the new Program Manager

Previously Nicole was DOLF’s Data Manager for 15 months before stepping into the role as Program Manager. Nicole served for one year in AmeriCorps conducting HIV prevention with high-risk populations in Cleveland, Ohio. After AmeriCorps, Nicole received her Master’s in Public Health from the Brown School at Washington University in St. Louis with a specialization […]

New clinical trial for treatment of LF in Cote d’Ivoire

DOLF project studies have demonstrated the safety and superior efficacy of IDA (a triple drug regimen of ivermectin, DEC, and albendazole) for treatment of lymphatic filariasis (LF). Moxidectin is a new drug that was recently approved for treatment of onchocerciasis. It is more effective than ivermectin for long-term clearance of O. volvulus parasites from the […]

DOLF Project Ophthalmologists Publish Short Case Report

DOLF project ophthalmologists Michael Gyasi and Augustine Hong have published a short case report of a patient with ocular onchocerciasis. This includes a photo and a very interesting video with motile microfilariae in the anterior chamber of the eye (open access, see “supplements”) that people may want to use for teaching or social mobilization. Microfilarial […]

DOLF Research-Roll-Out of IDA for LF Elimination in PNG (ENB)

Dr. Christopher King and his team from Case Western Reserve University and Dr. Alison Krentel from the Bruyere Research Institute in Ottawa have returned to East New Britain to continue their research. Dr. Krentel will train local staff on procedures for assessing the acceptability of the triple drug mass drug administration that was provided province-wide […]

DOLF initiates a trial of IDA triple drug treatment for Oncho

DOLF researchers and staff traveled to Hohoe, Ghana in December 2019 to work with Nick Opoku’s team at the University of Health and Allied Sciences to initiate a trial of the triple drug treatment IDA in persons with onchocerciasis. This study is testing the same IDA combination (ivermectin plus DEC and albendazole) that is so […]

Two New Members Join the DOLF Team

Nicole Fetcho joined the DOLF Project in October 2019 as a Statistical Data Analyst and Data Manager. Nicole is well prepared for this work with a Master of Public Health degree (with a focus on Biostati­­stics and Epidemiology) from the Brown School of Social Work at Washington University in St. Louis. Her MPH practicum work […]

Introducing Teresa Tufte – Global Health Program Manager

New Global Health Program Manager (Operations) – The DOLF Project Teresa joins the DOLF project as the Global Health Program Manager for Operations taking over for Rachel Anderson. She joins us with two years of health care research and data analysis experience at the State of Massachusetts’s Center for Health Information and Analysis. Prior to […]

DOLF Project Research On A New Treatment For LF Is Published In The NEJM

DOLF investigators Christopher King and James Kazura from Case Western Reserve University in Cleveland with colleagues at the Papua New Guinea Institute for Medical Research and at Washington University in St. Louis have just published important results from a randomized clinical trial. This trial tested the safety and efficacy of a new triple drug treatment […]

Introduction – Global Health Research Program Manager

The DOLF project is pleased to announce that Rachel Bick has joined our team as Global Health Research Project Manager Rachel brings international experience in global health and a strong academic background to this role. She holds a Bachelor of Science in Human Factors Psychology degree from the University of Utah and a Master of Public Health […]